Trial · Weerts et al., Gastroenterology(2020)
Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome(opens in a new tab)
- Findings and study population
- Randomized 190 adults; 189 analyzed. Small-intestinal or ileocolonic release, 182 mg three times daily for eight weeks, did not beat placebo on primary pain response or overall relief; some small-intestinal secondary outcomes improved.
- Limitations and differences from this claim
- Mild adverse events were more common with oil, and long-term benefit is unresolved. ZonMw funded it; WillPharma supplied products and collaborated, including support for an earlier trial. Authors report academic control of design and analysis. Products are not interchangeable.
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